Fig. 6
From: Analyzing exosomal miRNA profiles in tetralogy of fallot fetuses’ amniotic fluid
TBX5 is a direct target of miR-10a-5p. (A) The binding site of miR-10a-5p in the 3′-UTR of TBX5 was predicted by bioinformatics analyses. (B) Luciferase reporters expressing the wild-type or mutated 3′-UTR of TBX5 were designed according to miR-10a-5p seed sequences. (C) A dual-luciferase reporter assay was performed to verify that miR-10a-5p regulated the luciferase activity of TBX5 3’UTR- wild-type but did not influence that of Tbx5 3’UTR-mutated. **P < 0.01.
