Table 2 Associations between surrogate insulin resistance indexes and OA in NHANES 2003–2016.

From: Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016

OA

Model 1

Model 2

Model 3

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

TyG

Q1

Ref.

 

Ref.

 

Ref.

 

Q2

1.3318(1.0696, 1.6584)

0.011

1.0203 (0.8145, 1.2780)

0.860

0.9984 (0.7876, 1.2657)

0.989

Q3

1.7792 (1.4452, 2.1905)

< 0.001

1.2448 (0.9981, 1.5525)

0.052

1.2083 (0.9610, 1.5192)

0.104

Q4

2.0540 (1.6297, 2.5889)

< 0.001

1.3438 (1.0402, 1.7360)

0.024

1.2253 (0.9275, 1.6187)

0.151

P for trend

< 0.001

 

0.004

 

0.046

 

TyG-WC

Q1

Ref.

 

Ref.

 

Ref.

 

Q2

1.7893(1.4686, 2.1800)

< 0.001

1.3077 (1.0527, 1.6246)

0.016

1.3415 (1.0653, 1.6893)

0.013

Q3

2.1754 (1.7851, 2.6512)

< 0.001

1.5359 (1.2269, 1.9226)

< 0.001

1.5793 (1.2464, 2.0012)

< 0.001

Q4

3.1660 (2.5571, 3.9198)

< 0.001

2.3830 (1.9105, 2.9725)

< 0.001

2.3475 (1.8388, 2.9971)

< 0.001

P for trend

< 0.001

 

< 0.001

 

< 0.001

 

TyG-BMI

Q1

Ref.

 

Ref.

 

Ref.

 

Q2

1.5503(1.2263, 1.9600)

< 0.001

1.2116 (0.9467, 1.5506)

0.126

1.2621 (0.9793, 1.6265)

0.072

Q3

1.6813 (1.3996, 2.0197)

< 0.001

1.3624 (1.1103, 1.6718)

0.003

1.4468 (1.1637, 1.7987)

0.001

Q4

2.6510 (2.1435, 3.2787)

< 0.001

2.3825 (1.9140, 2.9657)

< 0.001

2.4969 (1.9808, 3.1474)

< 0.001

P for trend

< 0.001

 

< 0.001

 

< 0.001

 

TyG-WHtR

Q1

Ref.

 

Ref.

 

Ref.

 

Q2

2.0234(1.6705, 2.4509)

< 0.001

1.2869 (1.0383, 1.5950)

0.022

1.3036 (1.0439, 1.6280)

0.020

Q3

2.5759 (2.1177, 3.1334)

< 0.001

1.4970 (1.2120, 1.8489)

< 0.001

1.5825 (1.2587, 1.9894)

< 0.001

Q4

4.0636 (3.3238, 4.9679)

< 0.001

2.1933 (1.7535, 2.7433)

< 0.001

2.2444 (1.7604, 2.8615)

< 0.001

P for trend

< 0.001

 

< 0.001

 

< 0.001

 

VAI

Q1

Ref.

 

Ref.

 

Ref.

 

Q2

1.0333 (0.8368, 1.2759)

0.759

0.8968 (0.7229, 1.1126)

0.319

0.8802 (0.7069, 1.0961)

0.251

Q3

1.2674 (1.0621, 1.5125)

0.009

1.0029 (0.8379, 1.2005)

0.974

0.9773 (0.8098, 1.1793)

0.809

Q4

1.7325 (1.4268, 2.1037)

< 0.001

1.3677 (1.1111, 1.6836)

0.003

1.2597 (1.0103, 1.5708)

0.040

P for trend

< 0.001

 

0.002

 

0.016

 

LAP

Q1

Ref.

 

Ref.

 

Ref.

 

Q2

1.8001 (1.4373, 2.2543)

< 0.001

1.2246 (0.9700, 1.5460)

0.088

1.2126 (0.9574, 1.5359)

0.109

Q3

2.3063 (1.8488, 2.8772)

< 0.001

1.4184 (1.1245, 1.7890)

0.004

1.3925 (1.0964, 1.7685)

0.007

Q4

3.1026 (2.4690, 3.8988)

< 0.001

1.9879 (1.5776, 2.5049)

< 0.001

1.8395 (1.4515, 2.3312)

< 0.001

P for trend

< 0.001

 

< 0.001

 

< 0.001

 
  1. OA Osteoarthritis, BMI body mass index, WC waist circumferences, WHtR waist-to-height-ratio, TyG triglyceride-glucose index, VAI the visceral adiposity index, LAP lipid accumulation product, OR Odds Ratio, CI Confidence interva, Q Quartile, Ref Reference. Model 1 (unadjusted) did not adjust for any covariates. Model 2 adjustments were made for sex and age. Model 3 further adjustments for race, education level, poverty income ratio (PIR), drinking and smoking status, hypertension and diabetes. VAI and LAP did not need adjust for sex.
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