Fig. 6 | Scientific Reports

Fig. 6

From: lncRNA CHAF1B-2 contributes to the tumorigenesis of gastric cancer by activating the Wnt/β-catenin pathway

Fig. 6

Lnc-CHAF1B-2 activated the Wnt/β-catenin signalling pathway in gastric cancer. (A) Volcano plot and heatmap of the DEGs which were correlated with lnc-CHAF1B-2 expression in gastric cancer. (B) Association of lnc-CHAF1B-2 with genes encoding pivotal proteins within the Wnt/β-catenin signalling pathway, including β-catenin, GSK-3β, and cyclin D1, which correspond to the genes CTNNB1, GSK3B, and CCND1. (C) Western blot results showing the protein levels of β-catenin, GSK-3α/β, cyclin D1, and c-myc in gastric cancer cells following knocking down and overexpression of lnc-CHAF1B-2. NC: blank control group, Control: negative control, si-lnc-CHAF1B-2:small interfering RNA1, Vector: empty vector, lnc-CHAF1B-2-OE: lnc-CHAF1B-2 overexpression.

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