Fig. 4

Functional enrichment analysis of proteins in neonatal cord blood that change over gestational age. A) Heatmap of the protein Z-scores detected in neonatal cord blood samples arranged by gestational age from left to right. Proteins are grouped top to bottom by hierarchical clustering. Functional enrichment analysis and protein–protein interaction networks of proteins significantly B) decreased or C) increased over gestational age are shown below. Network nodes are shaded by abundance change over gestational age with edge width reflecting protein–protein interaction confidence. Significantly enriched pathways are highlighted in colored bar charts to the left; each protein that maps to the identified pathways is indicated by a color-matched box beneath the network node.