Table 3 mRNA network modules for seminoma, with preservation state shows mRNA seminoma vs. non-seminoma analysis results.

From: Networks of pre-diagnostic circulating RNA in testicular germ cell tumour

Module

Eigengenes

Top KEGG 2021 Pathway for Top 10 HUB genes

Top KEGG 2021 Pathway for All Genes in Module

Preservation state

E1

E2

E3

Black

USP14

GHRHR

CTNND1

-

-

Preserved (21)

Blue

UBE2W

OAS3

TNFAIP2

-

-

Preserved (114)

Brown

CFAP100

TTC7B

NRCAM

-

-

Preserved (181)

Cyan

RP1-27O5.3

PSEN1

CERKL

-

-

Preserved (26)

Darkgreen

NLRP11

DNAJB14

ADCY7

-

-

Preserved (12)

Darkred

HEPH

HMG20B

ZNF565

-

-

Preserved (6)

Green

DPPA2

PUDP

TMPRSS6

-

Ascorbate and aldarate metabolism

Preserved (44)

Greenyellow

GLIPR1

TBX18

ITPKB

-

-

Preserved (40)

Grey60

FAM151B

EEA1

RAD23B

-

-

Preserved (32)

Lightcyan

FASN

SCN2B

C1orf198

-

-

Preserved (8)

Lightgreen

PPP1R13B

UBXN8

ZNF280C

-

-

New

Lightyellow

UVSSA

KLHL21

FIGNL1

-

-

New

Magenta

SCN5A

CLUH

ST8SIA1

-

-

Preserved (115)

Midnightblue

ZC4H2

ATP1B1

GRID2

-

-

Preserved (17)

Pink

TBX5

HSPA9

EIF4G1

-

Shigellosis

Preserved (68)

Purple

RP11-729L2.2

SMAD4

PNPLA7

Viral myocarditis

-

Preserved (11)

Red

BEST3

SLC16A2

CAMK1D

-

T cell receptor signalling pathway

Preserved (151)

Royalblue

RAB8B

ZNF143

POM121C

-

-

Preserved (10)

Salmon

SHC3

UGGT1

IARS2

-

-

Preserved (9)

Tan

PDE6D

CENPN

LARP4

-

-

Preserved (20)

Turquoise

CHRNA7

NECTIN3

PPP1R9A

-

-

Preserved (549)

Yellow

PANK3

PANK2

COPZ1

Pantothenate and CoA biosynthesis

Hippo signalling pathway

Preserved (173)

  1. Included are the top three eigengenes in each module as well as enrichment analysis results for top 10 eigengenes and for all genes included in the module. Modules that were preserved show number of genes preserved between seminoma and non-seminoma. Rows in bold contain genes of interest within the eigengenes (E1, E2, E3). Additional information about mean, normalized expression of eigengenes E1 can be found in Supplementary Table 4.