Fig. 1

Circ_0043256 was up-regulated in GC tissues and CoCl2-induced MKN-45 and AGS cells. (A) Expression of hsa_circ_0043256 in GC tissues and normal tissues showed by GSE78092 database. (B) The expression of the top 25 up-regulated circ_RNAs in tumor tissues and adjacent non-tumor tissues was assayed by RT-qPCR analysis. Numbers indicate mean. (C) The expression of circ_0043256 in tumor tissues and adjacent non-tumor tissues was measured by RT-qPCR analysis. ^##P < 0.01 (vs. Control). (D) The expression of circ_0043256 in the control human gastric mucosal epithelial cells GES-1, the human GC cell lines MKN-45, AGS, SNU-16, SNU-216, HGC-27, and MKN-7 (#CL-0574) was tested by RT-qPCR analysis. ^*P < 0.05, ^**P < 0.01 (vs. GES-1). (C) The expression of circ_0043256 was measured by RT-qPCR analysis.^**P < 0.01 (vs. siRNA-NC), ^##P < 0.01 (vs. CoCl2 + siRNA-NC).