Fig. 4
Results of Cycle-GAN analysis. (A) shows that the outer portion of the glomerular capillary in cluster 1 images was erased, and Bowman’s spaces were enlarged. Generated images from cluster 9 revealed glomerular capillary structures or debris-like images in Bowman’s spaces (B). To emphasize the differences between the original and generated images, pseudo-colored images were created and overlayed. As shown in panel C, pseudo-colored images in green (left) represent the original images, and those pseudo-colored in red (middle) represent the generated images by Cycle-GAN. The images on the right represent the overlayed images. In the overlays of the original images from cluster 1 or 2 and generated images from cluster 9, the additional glomerular capillary structures are highlighted in red. In contrast, in the overlays of the original images from cluster 9 and generated images from cluster 1 or 2, the erased glomerular capillary structures are highlighted in green.
