Table 2 The complement proteins in the glomerular proteome between the DKD patients and normal controls.
Proteins | Normalized abundance in DKD | Fold change (DKD/controls) | P-value versus control | Fold change to controls | P-value between classes | |||
|---|---|---|---|---|---|---|---|---|
Class I DKD | Class II DKD | Class III DKD | Class IV DKD | |||||
C1qB | 234 | 5.6 | < 0.001 | 3.0 | 2.5 | 7.1 | 8.1 | 0.041 |
C1qC | 268 | 4.7 | < 0.001 | 1.2 | 1.6 | 6.1 | 7.4 | 0.004 |
C1r | 79 | 69.2 | < 0.001 | 86.3 | 27.8 | 80.1 | 93.9 | 0.088 |
C1s | 116 | 4.2 | < 0.001 | 1.3 | 1.6 | 5.8 | 6.2 | 0.004 |
C2 | 3 | 25.6 | < 0.001 | 5.5 | 24.3 | 33.3 | 25.9 | 0.276 |
C3 | 15,743 | 3.2 | < 0.001 | 1.6 | 2.1 | 3.6 | 4.4 | < 0.001 |
C4-A | 490 | 2.0 | 0.011 | 0.8 | 0.9 | 2.6 | 3.0 | 0.004 |
C4-B | 7991 | 4.8 | < 0.001 | 1.7 | 2.5 | 5.8 | 7.0 | 0.003 |
C5 | 4789 | 10.4 | < 0.001 | 3.6 | 4.8 | 12.7 | 16.1 | 0.001 |
C6 | 1350 | 19.1 | < 0.001 | 7.2 | 7.8 | 22.2 | 31.4 | 0.001 |
C7 | 1428 | 14.8 | < 0.001 | 5.3 | 6.2 | 16.8 | 24.7 | 0.001 |
C8α | 926 | 21.1 | < 0.001 | 6.0 | 8.1 | 26.0 | 34.2 | 0.001 |
C8β | 1384 | 12.5 | < 0.001 | 4.5 | 4.8 | 16.3 | 19.1 | 0.007 |
C8γ | 1397 | 13.7 | < 0.001 | 4.3 | 5.7 | 16.5 | 22.1 | 0.003 |
C9 | 11,845 | 7.2 | < 0.001 | 3.0 | 3.3 | 8.0 | 11.7 | 0.001 |
CFB | 115 | 4.5 | < 0.001 | 2.6 | 4.9 | 5.3 | 4.1 | 0.035 |
CFI | 6 | 11.4 | < 0.001 | 11.6 | 10.5 | 14.7 | 9.0 | 0.694 |
CFH | 1061 | 3.5 | < 0.001 | 1.7 | 2.3 | 4.1 | 4.7 | < 0.001 |
CFHR1 | 181 | 7.4 | < 0.001 | 3.7 | 4.0 | 8.0 | 11.5 | 0.002 |
CFHR3 | 256 | 22.0 | 0.019 | 21.9 | 1.4 | 27.8 | 36.7 | 0.327 |
CFHR5 | 484 | 6.7 | < 0.001 | 2.5 | 5.0 | 6.9 | 9.7 | 0.032 |
