Table 3 Potential biomarkers in HF based on UHPLC-QE-MS analysis in serum.
Mode | Metabolites | HMDB | RT | m/z | VIP | p value | FC | log2FC | Trend |
|---|---|---|---|---|---|---|---|---|---|
ESI (+) | PC 20:2_20:2 | – | 10.06 | 838.64 | 1.71 | 0.00 | 3.73 | 1.90 | up |
2-[(2-chlorobenzyl)sulfanyl]-4,6-dimethylnicotinonitrile | – | 2.26 | 311.04 | 2.40 | 0.00 | 0.27 | − 1.88 | down | |
LPC O-19:1 | – | 9.95 | 522.39 | 1.16 | 0.05 | 3.50 | 1.81 | up | |
Oleanolic acid | HMDB0002364 | 6.57 | 439.36 | 1.31 | 0.04 | 0.30 | − 1.72 | down | |
3,4,10,11-tetramethoxy-7,8,12b,13-tetrahydro-5H-6-azatetraphene | – | 5.48 | 356.19 | 1.24 | 0.04 | 0.37 | − 1.42 | down | |
PC 17:1_17:1 | – | 11.58 | 758.56 | 1.64 | 0.01 | 2.47 | 1.30 | up | |
N-acetyl-L-ornithine | HMDB0240589 | 1.95 | 175.11 | 1.28 | 0.04 | 042 | − 1.25 | down | |
Sulfisoxazole | HMDB0014408 | 5.89 | 290.06 | 1.23 | 0.04 | 2.32 | 1.21 | up | |
N′1-methyl-N′1-[2-nitro-4-(trifluoromethyl)phenyl]ethanohydrazide | – | 5.13 | 278.07 | 1.45 | 0.02 | 0.46 | − 1.20 | down | |
3-Nitro-L-Tyrosine | – | 5.27 | 249.05 | 1.39 | 0.02 | 0.27 | − 1.16 | down | |
1,2-Dipalmitoylphosphatidylglycerol | HMDB0251613 | 10.28 | 745.51 | 1.62 | 0.03 | 0.30 | − 1.11 | down | |
PC 18:1_18:2 | – | 9.70 | 784.58 | 1.63 | 0.00 | 0.37 | − 1.05 | down | |
Piperine | HMDB0029377 | 6.72 | 286.14 | 1.19 | 0.05 | 0.42 | − 1.04 | down | |
ESI (-) | Cyclamic acid | HMDB0031340 | 5.41 | 178.05 | 1.05 | 0.03 | 12.06 | 3.59 | up |
N-Acetyl-L-carnosine | HMDB0240589 | 6.16 | 267.11 | 4.48 | 0.04 | 7.29 | 2.87 | up | |
Naringenin | HMDB0002670 | 5.97 | 271.06 | 1.20 | 0.01 | 0.29 | − 1.79 | down | |
Prostaglandin A2 | HMDB0002752 | 6.01 | 667.41 | 1.10 | 0.03 | 0.35 | − 1.50 | down | |
Hex2Cer 13:0;2O | – | 7.50 | 628.33 | 1.96 | 0.00 | 0.39 | − 1.34 | down | |
Myricitrin | HMDB0034360 | 5.51 | 463.09 | 1.32 | 0.01 | 0.40 | − 1.33 | down | |
Anacardic acid | HMDB0033896 | 8.77 | 347.26 | 1.75 | 0.00 | 0.44 | − 1.18 | down |
