Fig. 7
From: Enhancing outcomes in Langendorff-perfused rodent hearts through perfusion parameter optimization
Influence of pharmacological treatment in cardiac injury and inflammatory markers. Concentration of Troponin I in the perfusate over time (A). Concentration of cardiac myocyte-associated proteins, a proxy for cardiac injury, quantified from the perfusate after 4 h (240 min) of perfusion, including Troponin T (B), creatine kinase – CKM (C), and myosin light chain 3 - MYL3 (D). Concentration of pro-inflammatory proteins including ICAM (E), IL-6 (F), and CXCL1 (G). Lactate accumulation over perfusion time (H). Repeated measures two-way ANOVA and Tukey-Kramer HSD post-hoc analysis on standard least squares means. All data are expressed as median ± interquartile range. * = p < 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001, **** = p ≤ 0.0001.
