Fig. 4
From: N-acetylcysteine stimulates organelle malfunction in endometriotic cells via IFN-gamma signaling
(a) Metabolomics analysis of 12Z cells revealed the altered metabolic processes (b, e) NAC treatment reduced key metabolic processes, including the Warburg effect, citric acid cycle, glutathione metabolism, and mitochondrial electron transport chain. (c, f) IFN-ɣ treatment decreased processes such as the urea cycle, glucose-alanine cycle, and malate-aspartate shuttle. (d, g) Combined IFN-ɣ+NAC treatment further suppressed pathways, including arginine-proline metabolism, branched-chain fatty acid oxidation, and phosphatidylethanolamine biosynthesis. (n = 3) (p < 0.05). The images were created via MetaboAnalyst (v 6.0).
