Table 1 Liposomes composition a) Lt total lipid amount; b) St total solid amount; c) DOTAP was fixed at 50 mol% for all formulations; d) DOPC amount changed according to the other components amount in the formulation; e) MSPL 1.66 mol% correspond to the ratio DOTAP:MSLP (w/w) 10:1, or DOTAP:MSLP (mol/mol) 30:1; f) final formulation volume DLS analyses.
Lta | Lta | Stb | DOTAPc | DOPCd | PTX | [PTX] | [PTX] | MSLPe | Vff | |
|---|---|---|---|---|---|---|---|---|---|---|
mM | mg | Mg | mol% | mol% | mol% | ug mL−1 | uM | mol% | mL | |
Lipo | 1 | 0.74 | 0.74 | 50 | 50 | 0 | 0 | 0 | 0 | 1 |
LipoPTX | 0.72 | 0.74 | 47 | 3 | 25.6 | 30 | 0 | |||
MSLP-Lipo | 0.71 | 0.76 | 45.34 | 3 | 25.6 | 30 | 1.66 |