Fig. 2 | Scientific Reports

Fig. 2

From: Toxoplasma GRA16 attenuates Tau hyperphosphorylation and enhances autophagy in thrombin-treated HT-22 hippocampal neuronal cells

Fig. 2

GRA16 upregulated PP2A and PTEN but downregulated GSK3β in thrombin-treated HT-22 cells. (A) GRA16 protein expression in the experimental HT-22 cell groups (control, vector, and GRA16) after thrombin treatment based on Western blot analysis; (B) PP2A-B55 protein expression in the experimental HT-22 cell groups after thrombin treatment based on Western blot analysis and their relative protein expression (n = 3); (C) Western blot image of PTEN and p-PTEN (Ser380) in the experimental HT-22 cell groups after thrombin treatment and their relative protein expression (n = 3); (D) Western blot image of GSK3β and p-GSK3β (Ser389) in the experimental HT-22 cell groups after thrombin treatment and their relative protein expressions (n = 3). †Significant at P < 0.05 between the control and GRA16 in the thrombin-treated experimental HT-22 cell groups. ‡ Significant at P < 0.05 between the vector and GRA16 in thrombin-treated experimental HT-22 cell groups.

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