Table 4 Kaplan–Meier analysis of CRC patients and association with Notch SNPs.
From: Role of Notch gene receptors as prognostic biomarkers in colorectal cancer
Parameters | n = 18 Event = Death | Mean Survival (%) | 1-year survival(%) | 3-year survival (%) | 95%CI | p-value |
|---|---|---|---|---|---|---|
Age | ||||||
< 40 | 07 | 36.9 | 94.7 | 60.2 | 28.7–45.2 | 0.344 |
> 40 | 11 | 49.9 | 84.8 | 75.2 | 43.5–56.3 | |
Gender | ||||||
Male | 09 | 41.4 | 88.7 | 73.7 | 36.0–46.9 | 0.412 |
Female | 09 | 43.4 | 85.0 | 65.0 | 34.0–52.8 | |
Tumor site | ||||||
Colon | 09 | 50.81 | 90.3 | 81.0 | 44.2–57.4 | 0.018 |
Rectum | 09 | 30.99 | 80.0 | 43.6 | 22.0–39.9 | |
Grade of differentiation | ||||||
Well | 04 | 35.8 | 90.9 | 54.5 | 24.5–47.1 | 0.557 |
Moderate | 13 | 47.0 | 84.5 | 72.4 | 40.1–53.9 | |
Poor | 01 | 27.8 | 83.3 | 83.3 | 23.9–31.7 | |
Tumor depth | ||||||
T1 | 00 | – | – | – | – | |
T2 | 02 | – | 77.8 | 77.8 | – | 0.444 |
T3 | 12 | – | 91.8 | 68.0 | – | |
T4 | 04 | – | 73.3 | 61.1 | – | |
Lymph node | ||||||
Positive | 12 | 30.6 | 77.4 | 42.6 | 22.7–38.5 | 0.001 |
Negative | 06 | 53.6 | 93.2 | 86.6 | 47.4–59.7 | |
TNM Staging | ||||||
I | 01 | 47.1 | 90.0 | 90.0 | 39.8–54.3 | 0.005 |
II | 05 | 50.4 | 93.8 | 83.4 | 41.5–59.2 | |
III | 10 | 33.9 | 80.2 | 51.5 | 26.0–41.8 | |
IV | 02 | 14.2 | 75.0 | – | 07.6–20.8 | |
LVI | ||||||
Present | 09 | 34.2 | 58.5 | 41.0 | 21.9–46.5 | 0.007 |
Absent | 09 | 47.6 | 92.5 | 80.8 | 42.1–53.0 | |
PNI | ||||||
Present | 06 | 27.1 | 81.8 | 40.9 | 17.8–36.4 | |
Absent | 12 | 49.8 | 88.5 | 77.2 | 43.7–55.9 | 0.017 |
Notch1 SNP | ||||||
CC | 10 | – | 84.7 | 62.6 | – | |
CT | 08 | – | 87.8 | 72.5 | – | 0.285 |
TT | 00 | – | – | – | – | |
Notch3 SNP | ||||||
AA | 11 | 48.6 | 90.0 | 71.2 | 41.7–55.5 | |
GA | 05 | 38.8 | 87.5 | 68.1 | 29.6–48.1 | 0.546 |
GG | 02 | 32.8 | 60.0 | 60.0 | 16.4–49.1 | |
Notch4 SNP | ||||||
CC | 08 | 51.8 | 90.8 | 78.7 | 45.5–58.1 | 0.081 |
CT | 08 | 34.1 | 82.1 | 53.9 | 24.7–43.4 | |
TT | 02 | 29.2 | 80.0 | 53.3 | 13.8–44.5 | |
