Fig. 3

68Ga-DOTATATE (A) and 18F-FDG PET/CT (B) images in a 43-year-old man with NPC. Intense 68Ga-DOTATATE uptake was observed in the bilateral cavernous sinuses (dotted arrows), suggesting intracranial invasion, but 18F-FDG PET/CT revealed no abnormal intracranial 18F-FDG uptake (dotted arrows). Moreover, 68Ga-DOTATATE PET/CT showed strong tracer uptake in the sphenoid, occipital and petrous bones (solid arrow). The extent of skull base bone invasion (solid arrows) shown by 18F-FDG PET/CT was significantly smaller than that shown by 68Ga-DOTATATE PET/CT. MRI (C) findings were matched with 68Ga-DOTATATE PET/CT.