Fig. 5 | Scientific Reports

Fig. 5

From: IFITMs exhibit antiviral activity against Chikungunya and Zika virus infection via the alteration of TLRs and RLRs signaling pathways

Fig. 5

CHIKV infection impairs the innate immune response in IFITMs-overexpressed HFF-1 cells. Plasmid control and IFITM1, 2, and 3 overexpressed cells were infected by CHIKV. After 48 h, the cells were collected for RNA extraction, RT-PCR and PCR array. (A) The results present as fold change of gene expression compared to infected-plasmid control cells. The upregulation was shown as orange to red while the downregulation was shown as blue. Three main innate immune pathways were demonstrated to be imbalanced by CHIKV including (B) TLR signaling pathway, (C) RLR signaling pathway, and (D) IFNs signaling pathway. - = uninfected cells, + = infected cells.

Back to article page