Fig. 8 | Scientific Reports

Fig. 8

From: Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy

Fig. 8

Network analysis of the anti-senescence mechanisms of Bufei Yishen formula. (A) UHPLC Q-Extractive Orbitrap-MS/MS was used to identify the compounds of the BYF4/5. (B) The compound and target network have been constructed. (C) volcano map (C) and cluster heatmap (D) were applied to showed the DEGs. (E) The PPI network of targets and DEGs was constructed The top 157 core nodes (F) with a degree value ≥ 70 were used for KEGG(https://www.kegg.jp/kegg/kegg1.html) pathway enrichment analysis (G). (H) Sankey diagram were used to shown the components, targets and their associated pathways.

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