Fig. 8
IP3 receptor antagonist 2-APB abolished agonist and EFS-evoked contractions in male USM. (A) Representative isometric tension recording from male USM showing contractions induced by increasing PE concentrations (30 nM − 30 µM) were abolished by the IP3-receptor (IP3R) antagonist, 2-APB (100 µM) (B). (C) Representative isometric tension recording from male USM showing contractions induced by EFS were inhibited by the IP3R antagonist, 2-APB (100 µM). (D) Summary effects of 2-APB on PE evoked contractions of male USM (n = 6). (E) Summary effects of 2-APB on EFS evoked contraction amplitude of male USM (n = 6).
