Fig. 1
From: NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy
Establishment of the pilocarpine-induced temporal lobe epilepsy rat model and comparison of rat epileptic behavioral results in different groups. (a) Pilocarpine-kindling progress. Following kindling, spontaneous recurrent seizures (SRS) were monitored for 3 months. Seizure activity was recorded and analyzed at three time points: 1, 2, and 3 months after SRS onset. Created on BioRender.com and licensed for publication. (b) Statistical results show that duration of seizures per day progressively increased (n = 6). (c) Statistical results show that total number of seizures per month progressively increased (n = 6). (d) Statistical results show that the duration of each seizure increased from the 0–1 month period to the 2–3 month period, while no significant difference was observed between the 1–2 month and 0–1 month periods, nor between the 1–2 month and 2–3 month periods (n = 6). (e) Statistical results show that total duration of seizures per month progressively increased (n = 6). Data are presented as means ± SEM (error bar) and compared using the two-sided Student’s t test; *P < 0.05; **P < 0.01; and ***P < 0.001; ns, no significance.
