Fig. 3
From: NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy
NLRP3 inflammasome-induced pyroptosis activation in pilocarpine-induced epileptic rats. (a) Western blot analysis of NLRP3, cleaved IL-1β, pro IL-1β, Gasdermin D-NT, cleaved caspase-1 in the hippocampus and temporal lobe cortex of the control group and epileptic (EP) rat group. The gels of different group (Hippocampus group and cortex group) were not cropped in the same gel. (b) Immunofluorescence staining of NLRP3 and IL-1β in the hippocampus and temporal lobe cortex showed increased fluorescence intensity in the EP group. Scale bar for fluorescence images: 100 μm. Unless specified otherwise, the data are presented as means ± SEM (error bar) and compared using the two-sided Student’s t test; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
