Table 4 Evaluation of IC50 values ​​for MAT, AMB, NCMAT, and NCAMB with and without light against promastigotes and amastigotes of L. tropica compared to MA and CC50 values ​​of drugs on macrophages to calculate the SI.

From: The synergistic anti-leishmanial effect of photodynamic therapy employing chemotherapy-mediated nanocomposites

 

IC50 Amastigotes

P Value

CC50 Macrophages

SI

MAT

97.0

NR

718.17

7.40

FNC

486.3

*

4765.74

9.80

AMB

108.6

*

733.84

6.76

NCMAT

69.4

*,#

597.46

8.61

NCAMB

76.2

*,#

625.32

8.21

MAT + L

67.2

*,&

491.07

7.31

AMB + L

74.1

*,&

508.11

6.86

NCMAT + L

56.03

*,#,&

468.65

8.36

NCAMB + L

60.2

*,#,&

489.34

8.13

  1. (*P < 0.001 with MA), (#P < 0.001 MAT or AMB vs. NC form), (& <0.001 with vs. without light).
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