Fig. 5

Activated CD4⁺ CD44⁺ T cells are proportionally increased in LACV-infected young NHP. PBMCs isolated from mock and LACV-infected weanling, juvenile and adult cynomolgus macaques were analyzed by flow cytometry for expression of T cell markers (A,B) including CD44 which is a marker of T cell activation (C,D). The proportion of CD4⁺ T cells was determined in LACV-infected weanling (E), and mock and LACV-infected juvenile (F) and adult (G) animals. Activated CD4⁺ CD44⁺ T cells were determined in the same animals (H-J). All data are presented as the proportion of T cells within total PBMCs.