Table 4 Risk values for different factors in univariate and multivariate analyses.

From: Machine learning for grading prediction and survival analysis in high grade glioma

Feature

HR (univariable)

HR (multivariable)

HR (final)

Minimum

0.80(0.60–1.08, P =0.142)

  

Skewness

1.21(0.99–1.47, P = 0.066)

  

Idn

0.83(0.69-1.00, P = 0.054)

  

Imc1

1.49(1.16–1.91, P = 0.002)

1.33(0.98–1.79, P = 0.066)

1.37(1.07–1.74, P = 0.012)

Inverse Variance

0.94(0.77–1.14, P = 0.519)

  

MCC

0.77(0.63–0.95, P = 0.001)

0.96(0.74–1.25, P = 0.761)

 

Large Area Low Gray Level Emphasis

0.67(0.39–1.15, P = 0.144)

  

Size Zone Nonuniformity

0.97(0.80–1.17, P = 0.728)

  

Joint Energy

0.91(0.73–1.13, P = 0.389)

  

IDH1

Wild

   

Mutant

0.39(0.23–0.67, P < 0.001)

0.55(0.30-1.00, P = 0.050)

0.54(0.30–0.97, P = 0.039)

MGMT

Negative

   

Positive

1.56(0.96–2.54, P = 0.071)

  

Ki_67

≤ 20

   

> 20

1.76(1.15–2.68, P = 0.009)

1.56(1.00-2.42, P = 0.050)

1.54(0.99–2.40, P = 0.053)

Sex

Female

   

Male

1.21(0.82–1.79, P = 0.341)

  

Operate

Part

   

All

0.66(0.45–0.98, P = 0.038)

0.70(0.46–1.06, P = 0.088)

0.69(0.46–1.03, P = 0.068)

Grade

III

   

IV

2.73(1.59–4.68, P < 0.001)

1.93(1.07–3.48, P = 0.029)

1.91(1.06–3.45, P = 0.030)

KPS

≤ 70

   

> 70

0.41(0.26–0.64, P < 0.001)

0.38(0.24–0.60, P < 0.001)

0.38(0.24–0.61, P < 0.001)

  1. Idn Inverse difference normalization, Imc1 Relevance Information Metric 1, MCC maximum correlation coefficient, KPS Karnofsky Performance Status.