Table 3 Clinical prediction model for IVF/ICSI outcomes constructed from univariate and multivariate logistic regression analysis.

From: Independent predictors and thresholds of in vitro fertilization outcomes in patients with diminished ovarian reserve

 

Univariate

 

Multivariate

OR (95% CI)

P value

AOR (95% CI)

P (a) value

Model 1

    

Age (years)

0.981 (0.941–1.024)

0.384

1.022 (0.980–1.067)

0.301

Anti-Mullerian hormone (ng/ml)

8.834 (4.053–20.29)

< 0.001*

4.043 (1.810–9.684)

0.001*

Antral follicle count

1.487 (1.301–1.710)

< 0.001*

1.335 (1.152–1.555)

< 0.001*

Basal follicle-stimulating hormone (IU/L)

0.952 (0.924–0.977)

< 0.001*

0.968 (0.945–0.993)

0.008*

Model 2

    

Age (years)

0.945 (0.918–0.972)

< 0.001*

0.973 (0.944–1.002)

0.070

Anti-Mullerian hormone (ng/ml)

4.117 (2.542–6.811)

< 0.001*

2.263 (1.392–3.804)

0.001*

Antral follicle count

1.330 (1.220–1.453)

< 0.001*

1.217 (1.109–1.339)

< 0.001*

Basal follicle-stimulating hormone (IU/L)

0.954 (0.930–0.977)

< 0.001*

0.973 (0.951–0.995)

0.017*

Model 3

    

Age (years)

0.917 (0.878–0.956)

< 0.001*

0.928 (0.887–0.969)

< 0.001*

Anti-Mullerian hormone (ng/ml)

1.467 (0.905–2.407)

0.120

0.927 (0.539–1.580)

0.781

Antral follicle count

1.187 (1.061–1.332)

0.003*

1.130 (0.999–1.280)

0.054

Basal follicle-stimulating hormone (IU/L)

0.974 (0.926–1.021)

0.292

1.000 (0.950–1.050)

0.963

D3-available cleavage stage embryos

1.240 (1.080–1.420)

0.001*

1.010 (0.836–1.230)

0.886

D3 top-quality cleavage stage embryos

1.377 (1.160–1.63)

< 0.001*

1.310 (1.040–1.650)

0.023*

Model 4

    

Age(years)

0.92 (0.875–0.966)

< 0.001*

0.959 (0.907–1.014)

0.142

Body-mass index(kg/m2)

0.92 (0.854–0.99)

0.026*

0.935 (0.859–1.017)

0.115

Retrieved oocytes

1.413 (1.231–1.622)

< 0.001*

0.965 (0.640–1.453)

0.863

Mature (MII) oocytes

1.572 (1.333–1.853)

< 0.001*

0.897 (0.599–1.342)

0.596

2PN embryos

1.818 (1.512–2.187)

< 0.001*

1.452 (0.304–6.931)

0.640

Normal cleavage embryos

1.832 (1.520–2.208)

< 0.001*

1.019 (0.233–4.45)

0.980

D3-available cleavage-stage embryos

2.264 (1.757–2.917)

< 0.001*

1.755 (1.123–2.742)

0.014*

D3 top-quality cleavage-stage embryos

1.766 (1.422–2.194)

< 0.001*

1.049 (0.545–2.016)

0.887

2PN rate (%)

3.826 (1.494–9.800)

0.005*

0.735 (0.060–9.071)

0.811

D3 top-quality cleavage stage embryo rate (%)

2.297 (1.030–5.122)

0.042*

1.439 (0.173–11.958)

0.736

  1. The odds ratios (ORs), 95% confidence intervals (CIs), and P values presented herein are derived from univariate analysis. Adjusted ORs (AORs), 95% CIs, and adjusted P values were computed using a multiple logistic regression model, where P(a) denotes the adjusted P value. Model 1 included factors associated with oocyte retrieval; Model 2 included factors associated with obtaining D3-available cleavage-stage embryos; Model 3 included factors associated with clinical pregnancy in fresh embryo transfer cycles; Model 4 included factors associated with viable blastocyst formation. IVF = in vitro fertilization, ICSI = intracytoplasmic sperm injection, DOR = diminished ovarian reserve, MII = metaphase II, 2PN = 2 pronuclei, D3 = Day 3.
  2. *P < 0.05.
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