Table 4 Performance comparison of predictors for IVF/ICSI outcomes in DOR patients.

From: Independent predictors and thresholds of in vitro fertilization outcomes in patients with diminished ovarian reserve

 

Predictors

AUC

P value

Cutoff value

Sensitivity (%)

Specificity (%)

Model 1

Anti-Mullerian hormone (ng/ml)

0.697 (0.637–0.756)

< 0.001*

0.345

56.1

73.15

Antral follicle count

0.696 (0.643–0.748)

< 0.001*

3.5

81.71

53.46

Basal follicle-stimulating hormone (IU/L)

0.630 (0.560–0.699)

< 0.001*

12.85

53.66

72.6

Model 2

Anti-Mullerian hormone (ng/ml)

0.649 (0.607–0.691)

< 0.001*

0.395

53.27

72.83

Antral follicle count

0.655 (0.614–0.696)

< 0.001*

3.5

69.35

57.7

Basal follicle-stimulating hormone (IU/L)

0.588 (0.543–0.632)

< 0.001*

10.95

59.8

56.36

Model 3

Age (years)

0.613 (0.559–0.666)

< 0.001*

35.5

45.36

72.67

D3 top-quality cleavage-stage embryos

0.619 (0.564–0.673)

< 0.001*

0.5

35.74

81.88

Model 4

D3-available cleavage-stage embryos

0.721 (0.667–0.776)

< 0.001*

3.5

77.78

57.5

  1. The receiver operating characteristic (ROC) curve was employed to assess the predictive efficacy of various factors on IVF/ICSI outcomes among DOR patients. The area under the ROC curve (AUC) was determined to quantify the predictive accuracy of these factors in predicting IVF/ICSI success. The Youden index, calculated as sensitivity plus specificity minus 1, was utilized to identify the optimal cut-off points, with the highest Youden index value selected for this purpose. Specifically, Model 1 assessed predictors for oocyte retrieval; Model 2 assessed predictors for obtaining D3-available cleavage-stage embryos; Model 3 assessed predictors for clinical pregnancy in fresh embryo transfer cycles; Model 4 assessed predictors for viable blastocyst formation. IVF = in vitro fertilization, ICSI = intracytoplasmic sperm injection, DOR = diminished ovarian reserve, D3 = Day 3.
  2. P < 0.05.
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