Fig. 4
From: Effect of dolutegravir-based antiretroviral therapy on glycemic control in female mice
DTG treatment is associated with increase in leptin receptor mRNA levels in muscle and liver. Leptin receptor mRNA levels (log-transformed) in muscle (A) and liver (C) of mice treated with either control (grey), 1xDTG (red), or 5xDTG (blue) following 9 weeks of treatment. Box plots show median (line), interquartile range (box), and range (whiskers), with individual data points shown. Statistical comparison by ANOVA with Tukey’s post-test. Correlations between muscle (B) and liver (D) leptin receptor mRNA levels and plasma leptin at week 9, assessed using Pearson r. N = 14 for control, N = 12 for 1xDTG, N = 15 for 5xDTG. ** p < 0.01, *** p < 0.001.
