Fig. 5
From: Effect of dolutegravir-based antiretroviral therapy on glycemic control in female mice
Hepatic and muscle gene expression in control, 1xDTG, and 5xDTG mice. Quantification of mRNA expression levels in liver (A–D) and muscle (E–G) tissue collected at time of sacrifice at 9 weeks of treatment in overnight fasted animals. (A) Fatty acid synthase (Fas), (B) diacylglycerol O-acyltransferase 1 (Dgat1), (C) acetyl-CoA carboxylase (Acc1), (D) insulin receptor substrate 2 (Irs2), (E) Cd36, (F) Irs1, (G) peroxisome proliferator-activated receptor gamma (Ppparγ). Data are log-transformed arbitrary units (AU) and are shown as box plots with the line indicating median, the box interquartile range, and the whiskers range, with individual data points shown. Statistical analyses using ANOVA with Tukey’s post-test. N = 14–15 for control, N = 12–13 for 1xDTG, N = 15 for 5xDTG. * p < 0.05, ** p < 0.01.
