Fig. 7
From: Effect of dolutegravir-based antiretroviral therapy on glycemic control in female mice
Gene expression profiles in muscle stratified by treatment and glycemia status. (A) Heat map showing means of log-transformed mRNA expression levels in the muscle stratified by treatment arm (control, 1xDTG, 5xDTG) and glycemia state (euglycemic (e) or hyperglycemic (h)). All control mice remained euglycemic. (B) Volcano plots showing mean difference for each group compared to control on the x-axis, and -log(q-value) on the y-axis for all genes. A positive mean difference indicates upregulation compared to control, a negative mean difference indicates downregulation compared to control. Anything above the horizontal dotted lines indicates significant difference. Statistical comparisons using false discovery rate of 10%. N = 6 for 1xDTG-euglycemic, N = 10 for 5xDTG-euglycemic, N = 6 for 1xDTG-hyperglycemic, N = 5 for 5xDTG-hyperglycemic.
