Table 3 Individual macular layer thicknesses in segmentation analysis.

From: Assessment of individual retinal layer thickness and vascular changes in Alzheimer’s disease

Parameter	AD					HC					p value
Parameter	Median	Min	Max	Q1	Q2	Median	Min	Max	Q1	Q2	p value
Retinal nerve fiber layer (µm)
C0	11	5	18	10	14	13	10	16	12	14	0.038
S1	23	19	43	20	27	24	18	34	22	26	0.437
T1	17	15	31	17	18	18	16	21	16	19	0.907
I1	24	20	33	22	27	25	19	32	22	27	0.855
N1	21	18	35	18	23	21	18	26	20	22	0.654
S2	40	29	83	36	43	38	29	54	35	42	0.419
T2	20	17	31	19	21	20	17	25	19	22	0.627
I2	39	25	52	32	42	40	30	54	35	44	0.363
N2	46	35	75	43	54	49	34	63	46	53	0.339
Ganglion cell layer (µm)
C0	12	8	20	10	16	15	11	24	13	19	0.025
S1	51	35	55	45	53	52	37	60	49	54	0.326
T1	45	31	56	38	48	47	35	56	42	51	0.155
I1	51	40	61	45	54	52	39	61	46	56	0.387
N1	50	38	62	41	51	50	36	58	47	54	0.321
S2	34	24	39	31	36	33	26	42	32	37	0.991
T2	33	19	46	31	38	35	28	46	32	38	0.538
I2	33	22	40	28	35	33	27	40	31	34	0.553
N2	37	29	41	32	39	36	30	44	34	39	0.991
Inner plexiform layer (µm)
C0	19	14	27	17	21	22	17	28	19	24	0.047
S1	41	31	45	36	43	41	37	49	38	44	0.278
T1	40	31	44	37	42	42	35	45	39	43	0.110
I1	40	34	53	37	42	41	32	47	38	43	0.465
N1	41	34	62	37	43	42	36	47	40	43	0.479
S2	27	22	31	24	29	27	21	33	26	29	0.783
T2	31	23	35	29	33	33	29	38	31	34	0.035
I2	26	20	36	24	28	27	21	32	25	28	0.530
N2	28	22	31	25	30	27	24	34	26	31	0.529
Inner nuclear layer (µm)
C0	20	13	29	17	22	23	14	31	19	26	0.027
S1	41	34	44	39	42	43	37	50	40	46	0.029
T1	37	26	42	33	41	39	33	45	38	42	0.008
I1	39	32	47	36	43	43	36	53	41	48	0.015
N1	39	34	46	36	43	44	38	50	41	46	0.004
S2	30	28	35	29	31	31	29	43	30	33	0.196
T2	32	28	36	30	34	33	30	38	32	35	0.071
I2	30	26	45	28	32	32	29	36	30	33	0.036
N2	33	30	37	31	34	33	30	38	32	35	0.124
Outer plexiform layer (µm)
C0	24	15	44	22	29	27	20	44	25	30	0.124
S1	33	26	52	29	39	31	27	51	28	36	0.399
T1	30	24	41	27	32	31	23	40	27	32	0.954
I1	34	24	53	28	38	35	26	53	31	38	0.473
N1	34	26	62	30	40	35	25	57	28	38	0.964
S2	27	24	33	25	28	26	23	32	25	27	0.389
T2	28	24	30	26	29	26	24	30	26	28	0.554
I2	27	23	33	25	29	28	24	34	26	29	0.286
N2	29	25	37	27	31	29	25	41	27	30	0.936
Outer nuclear layer (µm)
C0	91	70	110	80	97	96	80	108	91	105	0.015
S1	65	35	76	56	71	71	50	78	64	76	0.038
T1	71	57	82	64	72	77	46	94	73	80	0.005
I1	62	39	83	54	67	63	44	93	56	74	0.388
N1	65	47	81	56	72	71	44	89	65	76	0.122
S2	54	45	63	50	58	62	45	69	57	65	0.001
T2	53	42	62	50	55	59	43	68	53	63	0.007
I2	47	41	56	42	51	49	39	61	46	57	0.122
N2	52	41	65	46	55	52	43	67	51	60	0.101

Statistical significance was assessed using the Mann-Whitney U Test.
Significant values appear in boldface.
AD Alzheimer’s disease, HC healthy control, Min minimum, Max maximum, Q1 lower quartile, Q2 upper quartile, C0 central foveal thickness, S1 inner superior, N1 inner nasal, I1 inner inferior, T1 inner temporal, S2 outer superior, N2 outer nasal, I2 outer inferior, T2 outer temporal.

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Table 3 Individual macular layer thicknesses in segmentation analysis.

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