Fig. 1
From: Early, very high-dose, and prolonged vitamin C administration in murine sepsis
Effect of timing, dosing, and duration of vitamin C therapy on survival in septic mice. (A) Experimental design. (B) Ascorbic acid (AscA) was injected 1 h after cecal ligation and puncture (CLP) for 4 d (n = 9 in the sham; n = 20 in the CLP; n = 22 in the CLP + AscA90; n = 20 in the CLP + AscA180; and n = 24 in the CLP + AscA360). (C) AscA was injected 1 h after CLP for 8 d (n = 18 in the sham; n = 50 in the CLP; n = 47 in the CLP + AscA90; n = 30 in the CLP + AscA180; and n = 12 in the CLP + AscA360). (D) AscA was injected 6 h after CLP for 4 d (n = 9 in the sham; n = 22 in the CLP; n = 19 in the CLP + AscA90; n = 19 in the CLP + AscA180; and n = 13 in the CLP + AscA360). (E) AscA was injected 6 h after CLP for 8 d (n = 12 in the sham; n = 24 in the CLP; n = 22 in the CLP + AscA90; n = 17 in the CLP + AscA180; and n = 20 in the CLP + AscA360). *P < 0.05 when compared to the CLP group; log-rank test.
