Fig. 2
From: Early, very high-dose, and prolonged vitamin C administration in murine sepsis
Effect of very high-dose vitamin C administration on septic symptoms and the inflammatory response. (A) Ascorbic acid (AscA) was injected 1 h after cecal ligation and puncture (CLP) (n = 23 in the sham; n = 41 in the CLP; n = 41 in the CLP + AscA90; n = 30 in the CLP + AscA180; and n = 15 in the CLP + AscA360). (B) AscA was injected 6 h after CLP (n = 21 in the sham; n = 35 in the CLP; n = 35 in the CLP + AscA90; n = 44 in the CLP + AscA180; and n = 38 in the CLP + AscA360). (C) AscA was injected 1 h after CLP (n = 17 in the sham; n = 27 in the CLP; n = 30 in the CLP + AscA90; n = 20 in the CLP + AscA180; and n = 15 in the CLP + AscA360). (D) AscA was injected 6 h after CLP (n = 7 in the sham; n = 14 in the CLP; n = 15 in the CLP + AscA90; n = 21 in the CLP + AscA180; and n = 17 in the CLP + AscA360). Data are shown as the mean ± standard error of the mean. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001; one-way analysis of variance with Tukey’s multiple comparison test. IL: interleukin.
