Table 1 Associations of rapamycin with perioperative clinical frailty scores.

From: Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery

Subgroup

All mice (n = 39)

Old mice (n = 20)

Young mice (n = 19)

Rapamycin × timing of assessment

β *

95% C.I.

p-value

β *

95% C.I.

p-value

β *

95% C.I.

p-value

Rapamycin × pre-op

−0.48

−1.01, 0.06

0.083

−0.95

−1.86, −0.05

0.039

−0.01

−0.21, 0.20

0.958

Rapamycin × post-op 1 week

−1.10

−1.65, −0.55

< 0.001

−1.94

−2.85, −1.03

< 0.001

−0.25

−0.44, 0.05

0.015

Rapamycin × post-op 4 weeks

−1.29

−1.85, −0.74

< 0.001

−2.25

−3.17, −1.32

< 0.001

−0.32

−0.52, -0.11

0.003

Rapamycin × post-op 8 weeks

−1.31

−2.03, −0.59

< 0.001

−2.43

−3.61, −1.24

< 0.001

−0.23

−0.63, 0.18

0.272

AUC (Rapamycin)

0.079

0.164

0.004

AUC (no rapamycin)

0.025

0.034

0.021

  1. *Regression (beta) coefficients and 95% confidence intervals were derived from linear mixed effects model, using random slope and random intercepts within subjects, estimated with restricted maximum likelihood technique. Adjusted for the interaction term of timing of assessment * rapamycin use. Timepoint of assessment was modelled as a discrete variable. AUC refers to: area under the curve derived from the absolute change in frailty score from baseline.
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