Table 3 Analysis of influencing factors of DR among PLWHA with detectable viremia after ART.

From: HIV-1 subtype distribution and drug resistance profiles among PLWHA with detectable viremia in Henan Province, China, 2023

Characteristics

All(n, %)

DR(n, %)

OR (95% CI)

P

Adjusted OR (95% Cl)

P

Age at diagnosis,years, Median, (IQR)

49 (34, 58)

48 (34, 57)

    

 < 20

30 (3.73)

21 (70.00)

1.477 0.640–3.411)

0.361

0.174 (0.035–0.855)

0.031

20–29

106 (13.18)

70 (66.04)

1.231 (0.745–2.034)

0.418

0.415 (0.176–0.982)

0.045

30–39

141 (17.54)

88 (62.41)

1.051 (0.667–1.657)

0.830

0.876 (0.405–1.894)

0.736

40–49

136 (16.92)

112 (82.35)

2.954 (1.732–5.040)

0.000

0.356 (0.156–0.812)

0.014

50–59

207 (25.75)

142 (68.60)

1.383 (0.908–2.106)

0.131

0.799 (0.419–1.521)

0.494

 ≥ 60

178 (22.14)

109 (61.24)

1

 

1

 

Baseline CD4 + T cell count, cells/µL

      

 < 200

253 (31.47)

196 (77.47)

3.026 (1.589–5.764)

0.001

0.262 (0.109–0.628)

0.003

200–499

186 (23.13)

127 (68.27)

1.894 (0.988–3.632)

0.054

0.363 (0.157–0.839)

0.018

 ≥ 500

47 (5.85)

25 (53.19)

1

 

1

 

Log (Recent HIV viral load)

      

 < 3

109 (13.56)

65 (59.63)

1

 

1

 

3–4.99

507 (63.06)

362 (71.40)

1.690 (1.101–2.594)

0.016

0.489 (0.247–0.967)

0.040

 ≥ 5

172 (21.39%)

111 (64.53%)

1.232 (0.752–2.019)

0.408

0.657 (0.280–1.527)

0.329

Recent CD4 + T cell count, cells/µL

      

 < 100

327 (40.67)

237 (72.48)

1.445 (1.002–2.084)

0.049

2.643 (0.989–7.066)

0.053

100–249

240 (29.85)

159 (66.25)

1.077 (0.734–1.580)

0.705

2.431 (0.900–6.567)

0.080

 ≥ 250

223 (27.74)

144 (64.57)

1

 

1

 

HIV infection duration (years)

      

 ≤ 5

243 (30.22)

152 (62.55)

1

 

1

 

6–9

139 (17.29)

89 (64.03)

1.066 (0.691–1.643)

0.773

0.682 (0.178–2.615)

0.577

 ≥ 10

306 (38.06)

222 (72.55)

1.582 (1.102–2.271)

0.013

0.615 (0.179–2.105)

0.438

Time since ART initiation, median (IQR), years

5 (2.5–8.0)

5 (3–9.75)

    

 ≤ 1

126 (15.67%)

77 (61.11)

1

 

1

 

2–5

164 (20.40)

113 (68.90)

1.410 (0.866–2.296)

0.167

2.216 (0.883–5.560)

0.090

6–9

196 (524.38)

132 (67.35)

1.312 (0.823–2.092)

0.253

3.478 (0.855–14.154)

0.082

 ≥ 10

281 (34.95)

203 (72.24)

1.656 (1.063–2.580)

0.026

2.538 (0.540–11.915)

0.238

Initial ART regimen

      

NRTI + NNRTI

617 (76.74)

435 (70.50)

5.577 (2.506–12.409)

0.000

1.546 (0.279–8.554)

0.018

NRTI + PI/r

48 (5.97)

23 (47.92)

2.147 (0.818–5.632)

0.121

0.180 (0.043–0.746)

0.618

NRTI + INSTI

30 (3.73)

9 (30.00)

1

 

1

 

Unknown

109 (13.56)

78 (71.56)

    
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