Table 2 ConSurf prediction of evolutionary conservation and structural/functional categorization of SQLE mutations.
Amino acid change | Prediction score | ConSurf prediction | Functional/structural |
|---|---|---|---|
I121M | 5 | Average | – |
V237I | 8 | Conserved | |
F311L | 9 | Highly conserved | S |
L393S | 9 | Highly conserved | S |
L393F | 9 | Highly conserved | S |
S395P | 5 | Average | – |
F397L | 8 | Conserved | |
F397I | 9 | Highly conserved | S |
Q408L | 8 | Conserved | F |
F415S | 8 | Conserved | |
L437P | 9 | Highly conserved | S |
H440Y | 9 | Highly conserved | S |
H440T | 9 | Highly conserved | S |
S443P | 5 | Average | – |
