Table 4 Linear regression model to identify factors potentially associated with age at menopause.

From: Trends in age at natural menopause and menarche and related factors in Iran: results from a population-based study

 

Univariable models

P

Multivariable model

P

B

95%CI

 

B

95%CI

 

Education

      

 Primary

1.00 (ref.)

  

1.00 (ref.)

  

 Secondary

−1.34

−2.06, −0.62

< 0.001

0.59

−0.11, 1.30

0.10

 Higher

−4.41

−8.83, 0.01

0.05

−2.67

−7.08, 1.74

0.23

Employment

      

 Housewife

1.00 (ref.)

  

1.00 (ref.)

  

 Employed

−1.27

−1.87, −0.66

< 0.001

−0.32

−0.91, 0.26

0.27

Marital status

      

 Single

1.00 (ref.)

  

1.00 (ref.)

  

 Married

0.84

−1.25, −0.42

0.005

0.06

−0.49, 0.62

0.81

Smoking

      

 Yes

1.00 (ref.)

  

1.00 (ref.)

  

 No

1.23

0.44, 2.01

0.002

0.15

−0.58, 0.88

0.68

‌Breast cancer

      

 Yes

1.00 (ref.)

  

1.00 (ref.)

  

 No

4.74

0.62, 8.48

0.02

2.79

−1.23, 6.83

0.17

Hypertension

      

 Yes

1.00 (ref.)

  

1.00 (ref.)

  

 No

1.76

2.24, 1.27

< 0.001

0.84

0.34, 1.35

0.001

Thyroid disease

      

 Yes

1.00 (ref.)

  

1.00 (ref.)

  

 No

0.76

0.04, 1.49

0.03

0.75

0.07, 1.43

0.02

Diabetes

      

 Yes

1.00 (ref.)

  

1.00 (ref.)

  

 No

−0.5

−1.07, 0.06

0.08

−0.007

−0.54.0.53

0.97

CVA

      

 Yes

1.00 (ref.)

  

1.00 (ref.)

  

 No

0.9

0.50, 1.31

0.003

0.54

−0.03, 1.13

0.06

Rheumatic disease

      

 Yes

1.00 (ref.)

  

 No

0.51

−0.29, 1.31

0.21

Infertility

      

Yes

1.00 (ref.)

  

1.00 (ref.)

  

No

−0.37

−0.93, 0.17

0.18

−0.25

−0.78, 0.27

0.34

OCP

      

Yes

1.00 (ref.)

  

1.00 (ref.)

  

No

−0.38

−0.87, 0.10

0.12

0.16

−0.31, 0.65

0.49

Tubectomy

      

Yes

1.00 (ref.)

  

No

0.009

−0.49, 0.50

0.97

Age (y)

0.34

0.31, 0.38

< 0.001

0.29

0.24, 0.33

< 0.001

Marriage age

0.03

0.000, 0.07

0.04

0.01

−0.03, 0.05

0.62

Age at first birth (y)

0.05

0.02, 0.11

0.04

0.11

0.05, 0.17

< 0.001

Gravidity

0.38

0.31, 0.45

< 0.001

0.06

−0.25, 0.38

0.70

Number of live births

0.44

0.36, 0.52

< 0.001

0.18

−0.14, 0.51

0.27

Number of abortions

0.29

0.02, 0.56

0.03

−0.19

−0.59, 0.21

0.35

BMI

−0.01

−0.06, 0.04

0.69

Menarche age

0.29

0.05, 0.33

0.007

0.06

−0.06, 0.20

0.33

  1. Dependent variable: menopause age; overall sample size = 5311; Ref: Reference category; CVD: Cardiovascular disease, BMI: Body mass index, Oral Contraceptive Pills (OCP), Variables that had a P value ≤ 0.2 in the univariable models, were added in multivariable model.