Table 1 Target peptides included in the LC-HRMS/MS ITP for IASPs.

From: Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control

Drug candidate	Drug class	Ligand(s)	Subunit	Peptide#	AA#	Amino acid sequence	Monoisotopic mass [m/z]	Target Ion [m/z]	Charge	RT [min]
Garetosmab	Antibody	ActA	HC	T₃	44–64	GLEWIGYILYTGGTSFNPSLK	1158.60	1159.1029	2	11.5
Garetosmab	Antibody	ActA	LC	T₇	79–104	LEPEDFAVYYCQQYGSSPWTFGQGTK	1529.68	1530.1857	2	9.0
Sotatercept	Fusion protein	ActA, GDF-11	ActRIIA	T₂	5–19	SETQECLFFNANWEK	951.92	952.4205	2	7.5
Sotatercept	Fusion protein	ActA, GDF-11	Fc	T₂₄	224–231	ALPVPIEK	433.77	433.7723	2	4.8
Elritercept	Fusion protein	ActA, MSTN, GDF-11	modActRIIA	T₂	7–23	SETQECLFYNANWELER	1094.98	1095.4860	2	7.5
			modActRIIA	T₇	40–47	LHCYATWR	553.76	553.7641	2	4.0
			modActRIIA/ActRIIB	T₁₀	59–70	GCWLDDFNCYDR	810.81	810.8147	2	7.2
			modActRIIA	T₁₁	71–95	TDCVETEENPQVYFCCCEGNMCNEK	1587.09	1588.0937	2	5.7
Luspatercept	Fusion protein	GDF-11, MSTN	ActRIIB	T₂	4–16	ECIYYNANWELER	880.39	880.8912	2	6.2
			ActRIIB	T₆	33–40	LHCYASWR	546.76	546.7565	2	3.9
			modActRIIB	T₉	52–63	GCWDDDFNCYDR	811.79	811.7860	2	5.5
			ActRIIB	T₁₀	64–88	QECVATEENPQVYFCCCEGNFCNER	1600.62	1601.6214	2	6.2
Ramatercept	Fusion protein	MSTN, GDF-11, ActA	ActRIIB	T₂	4–16	ECIYYNANWELER	880.39	880.8912	2	6.2
			ActRIIB	T₆	33–40	LHCYASWR	546.76	546.7565	2	3.9
			modActRIIA/ActRIIB	T₉	52–63	GCWLDDFNCYDR	810.81	810.8147	2	7.3
			ActRIIB	T₁₀	64–88	QECVATEENPQVYFCCCEGNFCNER	1600.62	1601.6214	2	6.2
Apitegromab	Antibody	Latent/Pro-MSTN	LC	T₂	18–46	VTISCSGSSSNIGSNTVHWYQQLPGTAPK	1026.17	1026.4979	3	6.3
Apitegromab	Antibody	Latent/Pro-MSTN	LC	T₃	47–62	LLIYSDNQRPSGVPDR	915.48	915.4771	2	4.5
Landogrozumab	Antibody	MSTN	HC	T₅	44–65	GLVWVSAITSSGGSTYYSDTVK	1139.57	1140.0689	2	8.2
Landogrozumab	Antibody	MSTN	LC	T₄	47–62	LLIYSTSNLVAGIPDR	866.49	866.4865	2	7.8
Stamulumab	Antibody	MSTN	LC	T₁	1–30	SYELTQPPSVSVSPGQTASITCSGHALGDK	1025.50	1025.8259	3	5.7
Stamulumab	Antibody	MSTN	LC	T₂	31–60	FVSWYQQKPGQSPVLVIYDDTQRPSGIPER	1164.26	1164.6054	3	7.6
Domagrozumab	Antibody	MSTN, GDF-11	HC	T₄	44–65	GLEWVSTISSGGSYTSYPDSVK	1160.55	1161.0564	2	7.4
Domagrozumab	Antibody	MSTN, GDF-11	HC	T₁₈	222–247	THTCPPCPAPEAAGAPSVFLFPPKPK	925.46	925.8005	3	6.4
Mouse ActRIIA-Fc	Fusion protein	ActA	mouse ActRIIA	T₃	25–39	SETQECLFFNANWER	965.92	966.4237	2	7.6
Mouse ActRIIA-Fc	Fusion protein	ActA	mouse Fc	T₃₃	320–336	NTEPVLDSDGSYFMYSK	976.93	977.4350	2	6.5

HC heavy chain, LC light chain, Fc immunoglobin Fc fragment, ActRIIA/B activin type II receptor A/B, mod modified, AA amino acid, RT retention time.

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Table 1 Target peptides included in the LC-HRMS/MS ITP for IASPs.

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