Table 2 Subgroup univariate analysis of CMS-resembling groups. The CMS2-resembling subgroup served as the reference value.

Variable

HR (95% CI)

patients

HR (95% CI)

patients

HR (95% CI)

patients

HR (95% CI)

patients

Age

  < 69

1.00

92

1.24 (0.73–2.14)

38

1.13 (0.70–1.76)

74

1.41 (0.78–2.55)

28

  ≥ 69

1.00

74

2.05 (1.33–3.16)

38

1.57 (1.10–2.26)

110

1.58 (0.92–2.72)

24

Sex

 Female

1.00

77

1.80 (1.13–2.86)

41

1.47 (0.98–2.20)

83

1.05 (0.55–1.99)

24

 Male

1.00

89

1.38 (0.85–2.23)

35

1.42 (0.98–2.06)

101

1.84 (1.10–3.08)

28

Stage (TNM I–IV)

 I

1.00

36

2.87 (1.02–8.06)

9

2.16 (0.96–4.84)

37

1.63 (0.44–6.02)

7

 II

1.00

53

1.16 (0.63–2.15)

25

1.22 (0.74–2.02)

52

1.02 (0.42–2.48)

13

 III

1.00

55

1.40 (0.80–2.44)

27

1.56 (1.00–2.42)

63

1.54 (0.85–2.80)

23

 IV

1.00

21

2.01 (1.03–4.23)

15

1.19 (0.65–2.17)

32

1.36 (0.59–3.14)

9

pT

 1–2

1.00

44

2.94 (1.22–7.12)

11

2.31 (1.19–4.48)

51

1.61 (0.57–4.51)

10

 3–4

1.00

120

1.25 (0.86–1.80)

62

1.36 (1.00–1.84)

130

1.44 (0.93–2.22)

42

pN

 N0

1.00

92

1.67 (1.01–2.76)

37

1.39 (0.92–2.10)

95

1.33 (0.68–2.59)

22

 N+ 

1.00

72

1.41 (0.89–2.23)

37

1.59 (1.10–2.30)

85

1.43 (0.86–2.36)

30

pM

 M0

1.00

144

1.49 (1.02–2.19)

61

1.49 (1.09–2.02)

152

1.42 (0.90–2.25)

43

 M+ 

1.00

21

2.07 (1.02–4.19)

15

1.49 (0.80–2.76)

29

1.35 (0.58–3.12)

9

Grade (WHO)

 Low

1.00

145

1.47 (1.00–2.15)

57

1.46 (1.09–1.95)

157

1.42 (0.92–2.20)

43

 High

1.00

15

1.14 (0.49–2.65)

15

1.73 (0.75–3.97)

18

1.14 (0.39–3.36)

8

Tumor location

 Right colon

1.00

29

1.52 (0.84–2.76)

46

1.48 (0.83–2.67)

54

1.52 (0.63–3.71)

12

 Left colon

1.00

43

2.95 (1.32–6.60)

10

1.70 (0.98–2.93)

44

1.50 (0.52–4.31)

7

 Rectum

1.00

84

1.19 (0.66–2.15)

20

1.28 (0.87–1.87)

86

1.32 (0.80–2.19)

33