Table 3 Uni- and multivariable cox regression analysis for overall survival in colorectal cancer.
Clinicopathological variable | HR (95% CI) | p value | HR (95% CI) | p value |
|---|---|---|---|---|
Age | Univariable | Multivariable | ||
< 69 | 1.00 | 1.00 | ||
≥ 69 | 2.47 (1.98–3.10) | < 0.001 | 2.51 (1.97–3.19) | < 0.001 |
Sex | ||||
Female | 1.00 | |||
Male | 1.11 (0.89–1.37) | 0.36 | ||
Stage (TNM IV) | ||||
I | 1.00 | 1.00 | ||
II | 1.30 (0.91–1.86) | 0.145 | 1.58 (1.06–2.34) | 0.024 |
III | 2.03 (1.45–2.84) | < 0.001 | 2.52 (1.73–3.69) | < 0.001 |
IV | 5.84 (4.01–8.49) | < 0.001 | 6.51 (4.29–9.88) | < 0.001 |
Grade (WHO) | ||||
Low | 1.00 | |||
High | 1.17 (0.85–1.61) | 0.33 | ||
Tumor location | ||||
Right colon | 1.00 | |||
Left colon | 0.83 (0.61–1.13) | 0.23 | ||
Rectum | 0.97 (0.76–1.26) | 0.85 | ||
CMS-like group | ||||
CMS2-like | 1.00 | 1.00 | ||
CMS1-like | 1.57 (1.13–2.20) | 0.008 | 1.56 (1.12–2.18) | 0.009 |
CMS3-like | 1.45 (1.10–1.90) | 0.008 | 1.25 (0.93–1.61) | 0.15 |
CMS4-like | 1.45 (0.98–2.17) | 0.067 | 1.42 (0.95–2.12) | 0.087 |
