Fig. 1

Illustrates the construction of the IS scoring model. (A) Expression levels of risk genes across five independent datasets. (B) The impact of risk genes on patient prognosis. Orange represents risk genes, where high expression correlates with shorter survival time. Blue represents protective genes, where low expression correlates with shorter survival time. (C,D) Functional annotation of genes associated with colon cancer survival. (E) Heatmap of the distribution of clinical features for each sample. (F) Single-cell type annotation in colon cancer. (G) IS groupings for each cell type. (H) IS scores for various cell types.