Fig. 3

Subgroup analysis for convergence of hypoactivation in mood disorder patients during implicit emotion regulation. Activation likelihood estimation meta-analysis (n = 225) showing convergence of hypoactivation in mood disorder patients compared to healthy controls (patients > controls) during implicit emotion regulation. Three cluster regions with five peak coordinates were identified using a cluster-level family-wise error correction threshold of p < .05, with an uncorrected value of p < .001. A rigorous threshold of 5,000 permutations was applied. The first cluster reported a peak coordinate (x = 4, y = 38, z = 26) in the right and left medial frontal gyrus (BA9), extending over the anterior cingulate gyrus (BA32). The second cluster yielded two peak coordinates ([x = −64, y = −2, z = −14] and [x = −56, y = −6, z = −20]) in the left middle temporal gyrus (BA21), extending over the left superior temporal gyrus (BA22). Finally, two peak coordinates ([x = −26, y = −34, z = −18] and [x = −16, y = −38, z = −20]) were reported in the parahippocampal gyrus (BA36, BA35), spreading over the culmen. All locations were reported to be 100% grey matter. MedFG = medial frontal gyrus; ACG = anterior cingulate gyrus; MTG = middle temporal gyrus; STG = superior temporal gyrus; PHG = parahippocampal gyrus; CERB = cerebellum; ALE Score = ALE value.