Table 3 Significant clusters of activation likelihood estimation meta-analysis for whole-brain foci in mood and anxiety disorder patients and healthy controls during implicit emotion regulation at FWE p <.05.

Mood and anxiety disorders

Hypoactivation in patients (controls > patients)

Medial frontal gyrus, anterior cingulate gyrus

9, 32

R

928 mm³

4

38

26

0.023

Middle temporal gyrus, superior temporal gyrus

21, 22

L

1,216 mm³

−64

−2

−14

0.020

−56

−6

−20

0.017

Hyperactivation in patients (patients > controls)

Medial frontal gyrus, superior frontal gyrus, middle frontal gyrus

9, 10

L

736 mm³

−22

50

12

0.023

Mood disorders

Hypoactivation in patients (controls > patients)

Medial frontal gyrus, anterior cingulate gyrus

9, 32

R, L

1,128 mm³

4

38

26

0.023

Middle temporal gyrus, superior temporal gyrus

21, 22

L

1440 mm³

−64

−2

−14

0.020

Parahippocampal gyrus, culmen

36, 35

L

648 mm³

−26

−34

−18

0.018

Hyperactivation in patients (patients > controls)

Medial frontal gyrus, superior frontal gyrus, middle frontal gyrus

9, 10

L

1008 mm³

−22

50

12

0.023

Orbital gyrus

47, 11

R

872 mm³

20

20

−32

0.020

Inferior frontal gyrus

44, 45

L

512 mm³

−54

22

10

0.016

Middle frontal gyrus

47

L

552 mm³

−46

40

−8

0.017

Medial frontal gyrus

6

R, L

520 mm³

4

−2

52

0.017

Anterior cingulate gyrus, cingulate gyrus

32, 24, 33

L

752 mm³

0

26

16

0.017

Insula

13

R

536 mm³

42

2

14

0.017

Lentiform nucleus (putamen)

L

616 mm³

−26

−6

6

0.017

Claustrum

L

504 mm³

−38

−14

−4

0.016

Claustrum, insula

R

536 mm³

42

−14

−8

0.017

Anxiety disorders