Table 1 Clinical characteristics and serum vitamin levels in patients with dementias and controls.
From: Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases
Variable | Control (n = 280) | PD (n = 312) | AD (n = 219) | Other dementia(n = 115) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
M (P25, P75) | M (P25, P75) | χ2 or Z score | p value | M (P25, P75) | χ2 or Z score | p value | M (P25, P75) | χ2 or Z score | p value | |
Age (year) | 60.00 (55.00, 66.75) | 65.00 (57.00, 71.00) | − 3.739 | < 0.001 | 59.00 (55.00, 68.00) | − 0.017 | 0.987 | 67.00 (59.00, 72.00) | − 5.443 | < 0.001 |
Sex (n) | Male: 161 | Male: 193 | 1.166 | 0.280 | Male:97 | 0.585 | 0.003 | Male: 75 | 2.019 | 0.155 |
Female: 119 | Female: 119 | Female:122 | Female: 40 | |||||||
VB1 (ng/mL) | 2.50 (2.00, 3.28) | 1.70 (1.30, 2.20) | − 8.880 | < 0.001 | 1.80 (1.30, 2.30) | − 6.988 | < 0.001 | 1.70 (1.30, 2.30) | − 5.894 | < 0.001 |
VB2 (ng/mL) | 9.00 (5.61, 15.08) | 6.40 (4.13, 10.08) | − 5.499 | < 0.001 | 6.60 (4.50, 10.50) | − 4.733 | < 0.001 | 6.20 (4.30, 9.80) | − 3.950 | < 0.001 |
VB3 (ng/mL) | 34.69 (19.13, 45.13) | 38.10 (27.00, 44.15) | − 3.554 | 0.057 | 37.75 (27.90, 45.10) | − 4.061 | 0.070 | 32.20 (23.70, 41.40) | − 1.381 | 0.167 |
VB5 (ng/mL) | 42.15 (32.50, 55.85) | 33.90 (27.13, 39.75) | − 8.069 | < 0.001 | 33.30 (27.70, 41.80) | − 6.906 | < 0.001 | 34.60 (26.20, 42.30) | − 5.188 | < 0.001 |
VB6 (ng/mL) | 4.54 (2.95, 7.33) | 2.52 (1.13, 17.45) | − 3.229 | 0.001 | 1.89 (1.34, 2.73) | − 12.435 | < 0.001 | 2.13 (1.37, 4.96) | − 7.507 | < 0.001 |
5mTHF (ng/mL) | 8.45 (4.93, 16.28) | 4.85 (3.00, 7.70) | − 8.132 | < 0.001 | 5.40 (3.30, 9.00) | − 5.828 | < 0.001 | 4.50 (2.50, 8.10) | − 6.467 | < 0.001 |
VC (ng/mL) | 10.80 (7.60, 16.68) | 6.30 (3.43, 9.60) | − 10.887 | < 0.001 | 7.20 (4.30, 9.80) | − 9.181 | < 0.001 | 5.40 (3.00, 8.40) | − 9.435 | < 0.001 |
Hcy (µmol/L) | 8.02 (2.43, 10.40) | 13.75 (10.52, 18.02) | − 14.521 | < 0.001 | 11.47 (9.49, 14.09) | − 10.382 | < 0.001 | 13.73 (10.72, 16.75) | − 10.334 | < 0.001 |
