Table 4 Univariate and multivariate cox regression analyses for prediction of RFS.

Age (continuously coded)

1.01

0.98–1.03

0.788

Gender

Female versus male

0.74

0.38–1.46

0.388

Clinical T-stage

cT1 versus cTa/cTis

1.37

0.57–3.019

0.469

Tumor grade

High versus low

1.75

0.70–4.36

0.229

Concomitant CIS

Present versus absent

0.81

0.41–1.59

0.541

Lymphovascular invasion

Present versus absent

1.08

0.56–2.05

0.824

Histological subtypes

Present versus absent

1.88

1.13–3.14

0.015*

Pathological T-stage

pT ≤ 1

Reference

pT = 2

2.08

1.03–4.21

0.043*

pT ≥ 3

11

6.27–19.31

<0.001***

Pathological N-status

pNx

Reference

pN0

0.33

0.17–0.57

<0.001***

pN+

5.21

2.79–9.70

<0.001***

Histological subtypes

Absent

Reference

Present

1.21

0.71–2.05

0.489

Pathological T-stage

pT ≤ 1

Reference

pT = 2

2.08

1.02–4.25

0.044*

pT ≥ 3

9.37

4.85–18.10

<0.001***

Pathological N-status

pNx

Reference

pN0

0.25

0.14–0.44

<0.001***

pN+

1.03

0.49–2.16

0.929