Table 4 Comparison of clinicopathological characteristics between MUC5AC high-expression EPGA and MUC5AC low-expression EPGA.
From: Clinicopathological features and mucin expression of early papillary gastric adenocarcinoma
Characteristics | All (n = 116) | MUC5AC | P-value | |
|---|---|---|---|---|
High expression (n = 80) | Low expression (n = 36) | |||
Age (years) | 67 (59–71) | 66.0 (58.3–71.0) | 67.5 (61.5–72.0) | 0.527 |
Sex | 0.637 | |||
Male | 89 | 60 (75.0%) | 29 (80.6%) | |
Female | 27 | 20 (25.0%) | 7 (19.4%) | |
Location | 0.167 | |||
The cardia | 20 | 13 (16.3%) | 7 (19.4%) | |
The fundus | 4 | 4 (5.0%) | 0 (0%) | |
The corpus | 24 | 20 (25.0%) | 4 (11.1%) | |
The pylorus | 68 | 43 (53.8%) | 25 (69.4%) | |
Gross appearance | 0.029* | |||
Elevated | 63 | 49 (61.3%) | 14 (38.9%) | |
Non-elevated | 53 | 31 (38.8%) | 22 (61.1%) | |
Ulcer formation | 0.186 | |||
Present | 12 | 6 (7.5%) | 6 (16.7%) | |
Absent | 104 | 74 (92.5%) | 30 (83.3%) | |
Invasion depth | 1.000 | |||
Mucosa | 94 | 65 (81.3%) | 29 (80.6%) | |
Submucosa | 22 | 15 (18.8%) | 7 (19.4%) | |
Size (cm) | 2.15 (1.60–3.18) | 2.00 (1.53–3.08) | 2.40 (1.63–3.45) | 0.219 |
Differentiation | 0.686 | |||
Moderately | 66 | 47 (59.7%) | 19 (52.8%) | |
Well | 50 | 33 (41.3%) | 17 (47.2%) | |
Infiltrative pattern | 0.461 | |||
INFa | 96 | 68 (85.0%) | 28 (77.8%) | |
INFb | 14 | 9 (11.3%) | 5 (13.9%) | |
INFc | 6 | 3 (3.8%) | 3 (8.3%) | |
LVI | 0.034* | |||
Present | 11 | 4 (5.0%) | 7 (19.4%) | |
Absent | 105 | 76 (95.0%) | 29 (80.6%) | |
LNM | 0.094 | |||
Present | 2 | 0 (0%) | 2 (5.6%) | |
Absent | 114 | 80 (100%) | 34 (94.4%) | |
Histology | 0.071 | |||
High-grade | 62 | 38 (47.5%) | 24 (66.7%) | |
Low-grade | 54 | 42 (52.5%) | 12 (33.3%) | |
MUC2 | 0.184 | |||
High expression | 20 | 11 (13.8%) | 9 (25.0%) | |
Low expression | 96 | 69 (86.3%) | 27 (75.0%) | |
MUC6 | 0.017* | |||
High expression | 55 | 44 (55.0%) | 11 (30.6%) | |
Low expression | 61 | 36 (45.0%) | 25 (69.4%) | |
MSI status | 0.088 | |||
MSI-H | 17 | 15 (18.8%) | 2 (5.6%) | |
MSI-L/MSS | 99 | 65 (81.3%) | 34 (94.4%) | |
Ki-67 (positive index) | 60% (50%~70%) | 60% (50%~70%) | 65% (50%~70%) | 0.552 |
P53 | 0.414 | |||
Wild type | 69 | 50 (62.5%) | 19 (52.8%) | |
Mutation type | 47 | 30 (37.5%) | 17 (47.2%) | |
