Table 4 Imaging markers of glymphatic system that associated with 6-months MMSE and PSCI.

From: Glymphatic dysfunction as a biomarker for post-stroke cognitive impairment

 

Time 1

Time 2

B

95%CI

FDR P

B

95%CI

FDR P

6-months MMSE

 DTI-ALPS index of infarct side

14.091

2.841–25.341

0.031

8.799

− 8.063–25.660

0.522

 WM-PVS volume ratio of infarct side

1.432

0.417–2.447

0.045

0.905

− 0.096–1.906

0.213

 WM-PVS volume ratio of non-infarct side

1.564

0.415–2.714

0.03

0.987

0.127–1.848

0.155

6-months PSCI

 DTI-ALPS index of infarct side

0.001

0.001–0.122

0.045

0.005

0.001–0.849

0.215

 WM-PVS volume ratio of infarct side

0.779

0.547–1.108

0.413

0.830

0.641–1.076

0.397

 WM-PVS volume ratio of non-infarct side

0.794

0.524–1.204

0.463

0.813

0.644–1.026

0.135

  1. Adjust for baseline NIHSS score and infarct volume.
  2. PSCI post-stroke cognitive impairment, CI confidential interval, DTI-ALPS diffusion tensor image analysis along the perivascular space, PVS perivascular space, WM white matter, FDR false discovery rate.
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