Fig. 4
Single cell RNA-seq dissection of the immune microenvironment of VpR ccRCC tumours. (a) UMAP plot with identified cellular clusters. (b) Abundance of different immune cell types in normal and tumour samples. (c) Ratio of CD8+ T cells to regulatory T cells in normal and tumour samples. (d) Ratio of myeloid cells to CD8+ T cells in normal and tumour samples. (e) Single cell heatmap of gene expression in the indicated clusters of myeloid lineages and ccRCC cells pooled from three mouse ccRCCs. Each column represents a single cell. (f–i) Violin plots of abundance of the indicated mRNAs in cells of the indicated clusters. P values were calculated using Kruskal-Wallace non-parametric one-way ANOVA with Dunn’s multiple comparisons test.
