Fig. 1 | Scientific Reports

Fig. 1

From: Duloxetine deteriorates prefrontal noradrenergic pain facilitation, but reduces locus coeruleus activity to restore endogenous analgesia in chronic neuropathic pain state

Fig. 1

Effects of adrenoceptor antagonists administration to bilateral mPFC on the allodynia in SNL2W and SNL6W rats. Atipamezole (α2-adrenoceptor antagonist) or benoxathian (α1-adrenoceptor antagonist) was administered to the mPFC and the withdrawal threshold was assessed using the von Frey test over time (baseline 0, 15, 30, 60, and 90 min). In SNL2W rats, the drugs did not change the withdrawal threshold (A). However, atipamezole increased the withdrawal threshold in SNL6W rats (B). The same changes are observed in female SNL6W following atipamezole injection (C). The data are expressed as the mean ± SD, n = 8 each, †: p < 0.05 versus vehicle. Two-way repeated ANOVA followed by the Student’s t-test with Bonferroni’s correction for multiple comparisons. SNL; spinal nerve ligation, mPFC; medial prefrontal cortex.

Back to article page