Fig. 2 | Scientific Reports

Fig. 2

From: Duloxetine deteriorates prefrontal noradrenergic pain facilitation, but reduces locus coeruleus activity to restore endogenous analgesia in chronic neuropathic pain state

Fig. 2

The role of mPFC NA in analgesic effects of DLX alters over time following nerve injury. Intraperitoneal DLX (10 mg/kg) analgesia is attenuated in SNL6W (A). However, the changes in mPFC NA concentration following intraperitoneal DLX are not different between SNL2W and SNL6W (B). The time course of intra-mPFC injection of the α2-adrenoceptor antagonist, atipamezole combined with intraperitoneal DLX (10 mg/kg) is shown in (C). The combination did not change the anti-allodynic effects in SNL2W (D). However, the combination increased the DLX analgesia in SNL6W (E). The same changes are observed in female SNL6W (F). The data are expressed as the mean ± SD. n = 8 each (A, D, E) n = 6 each (B, F). *: p < 0.05 versus time 0, †: p < 0.05 versus corresponding control. #: p < 0.05 versus SNL6W rats. Two-way repeated ANOVA followed by the Student’s t-test with Bonferroni’s correction for multiple comparisons. SNL, spinal nerve ligation; mPFC, medial prefrontal cortex; NA, noradrenaline; DLX, duloxetine.

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