Fig. 1

Research Overview. Myocardial fibrosis after myocardial infarction is closely related to cardiac fibroblasts. Single-cell RNA sequencing revealed that C1 Postn + Fibroblasts was a key subset that exhibite higher myocardial fibrosis scores. The potential effect of Postn was demonstrated by in vitro experiments.Pathways such as Cxcl12-Ackr3 may provide new directions for intervention.