Fig. 1 | Scientific Reports

Fig. 1

From: Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy

Fig. 1Fig. 1

Identification of differentially expressed genes in GBM patients and their functional enrichment: (a) Volcano Plot of all the genes obtained on comparing the GBM samples from patients to normal brain samples. All the red dots correspond to the differentially upregulated genes, while all the green dots correspond to differentially downregulated genes. (b) Gene Ontology (GO) analysis of differentially expressed genes (DEGs) using DAVID (i) Functional annotation of upregulated DEGs. (ii) Functional annotation of downregulated DEGs (c.i) Bar graph representing all the significantly enriched KEGG pathways81 associated with upregulated DEGs, (c.ii) Bar graph representing all the significantly enriched KEGG pathways81 associated with downregulated DEGs, (d) Venn Diagram representing differentially expressed genes which were found to regulate cellular processes, intracellular processes, and receptor-mediated processes.

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